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Dynole 34-2
CAS No. 1128165-88-7
Dynole 34-2( —— )
Catalog No. M10451 CAS No. 1128165-88-7
Dynole 34-2 is a potent dynamin GTPase inhibitor with IC50 of 6.9 and 14.2 uM for full-length dynI and dynII GTPase activity, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameDynole 34-2
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NoteResearch use only, not for human use.
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Brief DescriptionDynole 34-2 is a potent dynamin GTPase inhibitor with IC50 of 6.9 and 14.2 uM for full-length dynI and dynII GTPase activity, respectively.
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DescriptionDynole 34-2 is a potent dynamin GTPase inhibitor with IC50 of 6.9 and 14.2 uM for full-length dynI and dynII GTPase activity, respectively; induces cytokinesis failure at the point of abscission, consistent with inhibition of dynamin while not affecting other cell cycle stages in cancer cells; disrupt midbody localization of calcineurin but not phospho-dynII and γ-tubulin, inhibits growth in a range of cancer cell lines with IC50 of 4.0 to 36.7 uM in MTT assays; Dynole 34-2 is a novel antimitotic compound acting specifically at the abscission stage.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetDynamin
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RecptorDynamin
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Research Area——
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Indication——
Chemical Information
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CAS Number1128165-88-7
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Formula Weight408.59
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Molecular FormulaC25H36N4O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (244.75 mM)
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SMILESCCCCCCCCNC(=O)C(=CC1=CN(C2=CC=CC=C21)CCCN(C)C)C#N
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Chemical Name2-Cyano-3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-N-octyl-2-propenamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Chircop M, et al. Mol Cancer Ther. 2011 Sep;10(9):1553-62.
2. Hill TA, et al. J Med Chem. 2009 Jun 25;52(12):3762-73.
3. Robertson MJ, et al. Nat Protoc. 2014 Apr;9(4):851-70.
4. Jackson J, et al. Mol Psychiatry. 2015 Jul;20(7):810-9.
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